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Therapeutic potential of ibogaine in treating addiction
de Donnová, Selma ; Vacek, Jaroslav (advisor) ; Minařík, Jakub (referee)
Presently, addiction constitutes a major global issue, both for people directly affected by it, and for society. Many people would benefit from innovative, safe, and effective treatments. Psychedelic renaissance in the 21st century brings potential solutions for some of the most common psychiatric issues, including addiction. The molecule subjected to the most extensive scientific research in this area is ibogaine - atypical psychedelic of plant origin displaying a complex mixture of dissociative, oneirophrenic, and hallucinogenic effects. This thesis is a non-systematic review of scientific literature published mostly after the year 2000, aiming to summarise information about the therapeutic potential of ibogaine in treating addiction, including risks, efficacy, and comparison to other types of treatment. Total number of citations included in this thesis is 92. Published scientific literature provides several general conclusions. Ibogaine is a potent substance that has caused several fatalities. These instances and further research suggest that ibogaine is dangerous particularly for people suffering from cardiovascular health conditions, in combination with other substances, and in absence of medical supervision. Clinical studies show, that in certain conditions, and in a controlled environment,...
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Impact of psychoactive drugs on the central nervous system
HRUBEŠOVÁ, Tereza
Substances of various origins belong among psychoactive drugs. These substances impact the central nervous system, where they affect cerebral function and cause temporary changes in perception, mood, consciousness and behaviour. This thesis presents a review of hallucinogens. Intoxication by these substances induces a state reminiscent of trance, dreaming or meditation which is exploited for recreation, ceremonial and mythological purposes around the world. Classification of psychoactive substances can be performed by many criteria, ranging from origin and chemical composition, through their effects on the central nervous system, to their legislative status. The first known use of psychoactive drugs dates to the Paleolithic period (2 500 000 A.C.N. - 8 000 A.C.N.). Their usage varies greatly among cultures; drug commonly used in one culture can be unknown to another one. Usage and popularity of psychoactive drug differ in ritual habits in cultures and across continents. In this Bachelor thesis, the mechanism of impact and signs of intoxication by six compounds are described. These include ibogaine, tropane alkaloids, harmala alkaloid, psilocybe, dimethyltryptamine and mescaline. Cultural and historical context is also provided.
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